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25OH Vitamin D
    INTENDED USE , The 25-hydroxy (25-OH) Vitamin D ELISA is intended for the quantitative determination of total 25-OH Vitamin D in human serum and plasma.
SUMMARY AND EXPLANATION

 Vitamin D is a steroid hormone involved in the active intestinal absorption of calcium and in the
regulation of its homeostasis. Vitamin D has two isomers: Vitamin D2 and Vitamin D3. Vitamin D2 is
obtained from dairy products whereas Vitamin D3 is produced in the skin after exposure to ultraviolet
light. In the liver, Vitamin D is hydroxylated at its carbon 25 to form 25-OH Vitamin D. This metabolite is
the predominant circulating form of Vitamin D and is considered to be an accurate indicator of the
general Vitamin D status of an individual. Vitamin D deficiency has been linked to many diseases
including osteoporosis, rickets, osteomalacia, cancers, and cardiovascular diseases. Both dietary
supplements of Vitamin D that are currently available in the market (Vitamin D2 and Vitamin D3) are converted to 25-OH Vitamin D in the liver. The sum of the concentrations of 25-OH Vitamin D2 and 25OH
Vitamin D3, in serum or plasma, is referred to as “Total 25-OH Vitamin D”. Accurate monitoring of
total 25-OH Vitamin D level is critical in clinical settings. Vitamin D deficient patients who are prescribed
a daily Vitamin D supplement should regularly monitor their serum or plasma Vitamin D levels in order to
reach an optimal level and prevent their 25-OH Vitamin D concentrations from reaching excessive levels
that are considered toxic